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Biology

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Beriberi is a disease that results from a dietary lack of thiamine, the vitamin that serves as the precursor for thiamine pyrophosphate (TPP). There are two metabolites that accumulate in individuals with beriberi, especially after ingestion of glucose. Which metabolites accumulate and why?

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Pyruvic acid and lactic acid (products of carbohydrate digestion) accumulate in the tissues.

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