Answer :
The Krebs Cycle requires NAD+ and FAD+ from the electron transport chain and operates thanks to several different enzymes that completely oxidize Acetyl-CoA.
Aerobic respiration takes place in two stages: the Krebs cycle and electron transport and oxidative phosphorylation (these last two processes occur in a coupled manner).
- The Krebs cycle takes place in the mitochondria and allows carbohydrates, lipids and amino acids to be completely oxidized, producing a large amount of metabolic energy.
- For the cycle to begin, it needs to acetyl-CoA, coming from the degradation of more complex molecules, to give rise to citric acid.
- In the electron transport chain each molecule of NADH becomes 3 ATP (2 NADH x 3 = 6 ATP).
- The conversion of pyruvic acid to AcetylCoA in the mitochondrial matrix yields 2 NADH for each glucose molecule. (2 NADH x 3 ATP = 6 ATP).
- Two molecules of acetyl-CoA enter the Krebs cycle and give two of GTP and 6 NADH and 2 FADH2.
Therefore, we can conclude that the Krebs Cycle is a fundamental process that occurs in the matrix of cellular mitochondria, and that it consists of the release of the chemical energy contained in Acetyl-CoA.
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