The two systems that are most likely to interact when a person feels itchy from a skin irritant are the nervous system and the immune system.
What is the physiological explanation of itching?
In general, itching is a signal sent by nerves from the skin to the brain after the immune system releases substances - such as histamine - in response to irritation.
With this information, we can conclude that the two systems that are most likely to interact when a person feels itchy from a skin irritant are the nervous system and the immune system.
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