If Phineas's doctors knew what we now know about infections, they would have been able to treat Gage's condition better.
Phineas Gage was a notable patient in the history of Psychology. While working in the Americal Railway Corporation, he sustained an injury where an iron rod pierced his skull damaging a large part of his frontal lobe.
His condition taught psychologists that there was a strong connection between the frontal lobe and the personality of a person.
At this time, around 1848, doctors didn't know anything about microscopic organisms let alone infctions. (Page 12)
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