When two sides of a membrane are in contact with each other, the distribution of ions will alter as a result of the binding of a signal molecule to a ligand-gated ion channel.
Ligand-gated ion channels (LGICs) are membrane proteins that are structurally integral and feature a pore that permits the controlled passage of particular ions across the plasma membrane. The electrochemical gradient for the permeant ions drives the passive ion flux.
When a chemical ligand, such as a neurotransmitter, attaches to the protein, ligand-gated ion channels open. Changes in membrane potential cause voltage channels to open and close. When a receptor physically deforms, as in the case of pressure and touch receptors, mechanically-gated channels open.
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