A DNA base is altered biochemically during DNA methylation, which typically takes place during gametogenesis and after fertilization.
- The DNA methyltransferases DNMT1, DNMT3A, and DNMT3B keep methylation marks in tact after each cell division.
- Although the majority of methylation marks are stable, there is typically 10% to 20% variation over time. Ly cytosine undergoes enzymatic 5-carbon methylation.
- DNA methylation represents the best characterized form of epigenetic modification. DNA methylation is written onto the genome by two methyltransferases, known as Dnmt3a and Dnmt3b.
- These enzymes catalyze the addition .
- Aging is often marked by the establishment of global hypomethylation and regions of CpG island hypermethylation.
- These changes in the epigenetic landscape may contribute to aging by adversely affecting genomic stability and gene regulation.
- Thus, DNA methylation has its affect on aging and thus should be observed carefully.
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