There are millions of these alleles, yet each B or T cell can only detect one antigen per cell. Only activated B and T cells will continue to divide, creating a powerful reservoir of lymphocytes that are specialized to particular pathogens.
In the bone marrow, both types of cells are produced. While T cells travel to the thymus and develop there, B cells develop in the bone marrow. Antigens bind to receptors on the cell surface of B lymphocytes, activating them and causing them to divide and proliferate. MHC class ll molecules, which are expressed on the surface of antigen-presenting cells, present peptide antigens to hyper T cells, activating them.
Antibodies produced and secreted by B cells stimulate the immune system to attack invaders. The primary distinction between T cells and B cells is that whereas B cells can detect the surface antigens of bacteria and viruses, T cells can only recognize viral antigens that are present outside of infected cells.
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