you plan to model a loss of function mutations could lead to over expression of the her2 protein using crispr/cas 9. which genomic locus should you target your sgrna to generate this loss of function mutation?

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you plan to model a loss of function mutations could lead to over expression of the her2 protein using crispr/cas 9. which genomic locus should you target your sgrna to generate this loss of function mutation?

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Abhinavjh321go Abhinavjh321go · Answer 1

direct sgRNA towards the chromosomal locus encoding the ERBB2 repressor protein. Plan to use crispr/cas 9 to simulate how a loss of function mutation may cause the her2 protein to be overexpressed.

The erbB2 gene, commonly referred to as HER2 or neu, produces a 185-kDa transmembrane glycoprotein that is a member of the EGFR family of epidermal growth factor receptors. The ERBB2 gene, a transmembrane receptor tyrosine kinase, encodes the human epidermal growth factor receptor 2 (also known as HER2 or HER-2/neu). An intrinsically active receptor tyrosine kinase, ErbB2 functions as a tyrosine kinase. The epidermal growth factor receptor and HER2 are both members of the ErbB family of transmembrane receptor tyrosine kinases.

learn more about HER2 protein here:

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